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Liver-directed treatment is associated with improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results from a retrospective multicenter trial

Frontiers of Medicine   Pages 878-888 doi: 10.1007/s11684-023-0993-y

Abstract: Metastases of uveal melanoma (UM) spread predominantly to the liver. Due to low response rates to systemic therapies, liver-directed therapies (LDT) are commonly used for tumor control. The impact of LDT on the response to systemic treatment is unknown. A total of 182 patients with metastatic UM treated with immune checkpoint blockade (ICB) were included in this analysis. Patients were recruited from prospective skin cancer centers and the German national skin cancer registry (ADOReg) of the German Dermatologic Cooperative Oncology Group (DeCOG). Two cohorts were compared: patients with LDT (cohort A, n = 78) versus those without LDT (cohort B, n = 104). Data were analyzed for response to treatment, progression-free survival (PFS), and overall survival (OS). The median OS was significantly longer in cohort A than in cohort B (20.1 vs. 13.8 months; P = 0.0016) and a trend towards improved PFS was observed for cohort A (3.0 vs. 2.5 months; P = 0.054). The objective response rate to any ICB (16.7% vs. 3.8%, P = 0.0073) and combined ICB (14.1% vs. 4.5%, P = 0.017) was more favorable in cohort A. Our data suggest that the combination of LDT with ICB may be associated with a survival benefit and higher treatment response to ICB in patients with metastatic UM.

Keywords： uveal melanoma     liver-directed therapy     immune checkpoint blockade     SIRT     anti-PD-1     anti-CTLA-4    

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Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Frontiers of Medicine   Pages 805-822 doi: 10.1007/s11684-023-1025-7

Abstract: To date, immune checkpoint inhibitors (ICIs) of CTLA-4 and PD-1/PD-L1 represent the main class of immunotherapyBlockade of CTLA-4 and PD-1/PD-L1 has shown remarkable efficacy in several specific types of cancers,demonstrate the generalized mechanism of targeting cancer metabolism at three crucial immune checkpoints (CTLA-4, PD-1, and PD-L1) to influence ICB therapy and propose potential combined immunotherapeutic strategies

Keywords： CTLA-4     PD-1     PD-L1     immune checkpoint blockade (ICB)     metabolic reprogramming     combined tumor therapeutic    

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Design, synthesis and HIV-RT inhibitory activity of novel thiazolidin-4-one derivatives

Hua CHEN, Zaihong GUO, Qingmei YIN, Xiaoxu DUAN, Yunjing GU, Xiaoliu LI

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 2,   Pages 231-237 doi: 10.1007/s11705-010-1022-7

Abstract: A series of 2-aryl-3-(4,5,6-trimethylpyrimidin-2-yl) thiazolidin-4-ones ( – ) and their derivatives bearingsubstituent, like acetoxy group ( – ), propionyloxy group ( – ), methyl ( and ) at C-5 on thiazolidin-4-Preliminary anti-HIV-RT test of these derivatives indicated that compounds – , (propionyloxy groupactivity relationship analysis suggested that the substituted groups on C-5 would be unfavorable to anti-HIV-RTactivity and that the steric effect might play a critical role in the anti-HIV RT activity.

Keywords： 5-subsituted thiazolidin-4-ones     Pummerer reaction     anti-HIV-RT activity     SARs    

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Antibacterial and anti-flaming PA6 composite with metathetically prepared nano AgCl@BaSO

Wei Zhang, Boren Xu, Caihong Gong, Chunwang Yi, Shen Zhang

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 2,   Pages 340-350 doi: 10.1007/s11705-020-1942-9

Abstract: addition of AgCl@BaSO co-precipitates, the antibacterial performance, along with the flame-retardance and anti-dripping

Keywords： nano AgCl@BaSO4 co-precipitates     antibacterial     flame resistance     PA6 composite     PA6 yarn    

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QUANTITATIVE STUDY ON ANTI-PEST ACTIVITY OF NATURAL PRODUCTS BASED ON VISUALIZATION FRAMEWORK OF KNOWLEDGE

Frontiers of Agricultural Science and Engineering 2023, Volume 10, Issue 2,   Pages 306-332 doi: 10.15302/J-FASE-2023488

Abstract:

● Using visual analysis to predict the trend of natural product pest resistance.

Keywords： anti-pest activity     crop protection     insect pest     natural product     visual analysis    

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Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 729-746 doi: 10.1007/s11684-022-0978-2

Abstract: The effect of anti-programmed cell death 1 (anti-PD-1) immunotherapy is limited in patients with hepatocellularThe response to anti-PD-1 treatment is associated with A. muciniphila abundance in many tumorsHere, anti-PD-1 treatment decreased A. muciniphila abundance in the colon, but increased YAP1Yap1 knockout enhanced anti-PD-1 efficacy.Our findings suggested that the combination anti-PD-1 with DHA is an effective strategy for liver tumor

Keywords： hepatocellular carcinoma     YAP1     Akkermansia muciniphila     anti-PD-1     dihydroartemisinin     bile acid    

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A modular cable-driven humanoid arm with anti-parallelogram mechanisms and Bowden cables

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 1, doi: 10.1007/s11465-022-0722-2

Abstract: This paper proposes a novel modular cable-driven humanoid arm with anti-parallelogram mechanisms (APMs

Keywords： modular robotic arm     anti-parallelogram mechanism     Bowden cable     humanoid arm     lightweight joint design    

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Anti-biofouling strategies for implantable biosensors of continuous glucose monitoring systems

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12,   Pages 1866-1878 doi: 10.1007/s11705-023-2340-x

Abstract: review, research efforts over the past few years to mitigate the immune responses by enhancing the anti-biofoulinglayers on the biosensor surface, such as drug-releasing membranes, hydrogels, hydrophilic membranes, anti-biofoulinginformation, which is likely to aid in the research and development of novel CGM systems with profound anti-biofouling

Keywords： implantable glucose biosensor     anti-biofouling     continuous glucose monitoring     immune responses    

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Lignin-derived dual-function red light carbon dots for hypochlorite detection and anti-counterfeiting

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 7,   Pages 966-975 doi: 10.1007/s11705-022-2244-1

Abstract: Compared with green and blue fluorescent materials, red SPN-CDs have desirable anti-interference properties

Keywords： alkali lignin     red light carbon dots     hypochlorite     encryption and anti-counterfeiting    

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Modulatory effect on dyslipidemia and anti-atherosclerotic function of in newly diagnosed type 2 diabetes

SUN Mingxiao, WANG Yao, CHI Jiamin

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 174-177 doi: 10.1007/s11684-008-0032-z

Abstract: The modulatory effect of on dyslipidemia and the preventive effect on atherosclerosis in newly diagnosed type 2 diabetic patients were studied. A prospective clinical trial was conducted to test the effectiveness of in selected 201 newly diagnosed type 2 diabetic patients. All patients were randomly divided into two groups: 108 with therapy and 93 without therapy. The mean follow-up period was 22 months. The blood glucose and blood pressure of all patients were under control. Serum levels of total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) were significantly lowered and their decreased percentages were significantly higher in therapy group ( < 0.05). The number of patients with arteria iliaca intima thickening was significantly lower in group of therapy ( = 0.024). With stepwise multivariate logistic regression analysis, the decreased percentage of TG was significantly and independently related with the decreased number of patients with arteria iliaca intima thickening ( = 0.005). The study demonstrates that therapy is effective on modulating dyslipidemia in newly diagnosed type 2 diabetes patients, and may be related with the improvement of early atherosclerosis.
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Preparation of reverse osmosis membrane with high permselectivity and anti-biofouling properties for

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 7, doi: 10.1007/s11783-021-1497-0

Abstract:

• Nanoparticle incorporation and anti-biofouling grafting were integrated

Keywords： Anti-biofouling grafting     Nanoparticle incorporation     Sterilization rates     Water flux     Water flux recovery    

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Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)

Frontiers of Medicine doi: 10.1007/s11684-023-1037-3

Abstract: To date, four domestically developed oral anti-COVID-19 drugs have been granted conditional market approvalwill expand our understanding and highlight the potential widespread application of China’s homegrown anti-COVID

Keywords： COVID-19     antiviral drugs     mindeudesivir    

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Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion

Liyuan Chen, Qifeng Dang, Chengsheng Liu, Jun Chen, Lei Song, Xiguang Chen

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 195-203 doi: 10.1007/s11684-012-0189-3

Abstract:

The purpose of this study was to improve the dissolution rate and anti-inflammatory effect of ibuprofenThe anti-inflammatory effect of SDBT was evaluated using the mouse ear edema test with xylene.SDBT displayed more significant anti-inflammatory effects than CT.The dissolution rate and anti-inflammatory effect of ibuprofen were significantly enhanced by the ibuprofen-urea

Keywords： ibuprofen     solid dispersion     physical mixture     dissolution     anti-inflammatory effect    

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Mobile CRISPR-Cas9 based anti-phage system in E. coli

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 8,   Pages 1281-1289 doi: 10.1007/s11705-022-2141-7

Abstract: Here, we developed a mobile CRISPR-Cas9 based anti-phage system for bacteriophages defense in E. coli

Keywords： phage infections     anti-phage     CRISPR-Cas9     conjugative transfer     synthetic biology    

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Impact of Recent Regional Wars on Requirements of Ground based Air Defense Radars

Peng Jiating

Strategic Study of CAE 1999, Volume 1, Issue 2,   Pages 19-23

Abstract: targets as the cruise missile, attack helicopter, lowaltitude aircraft (including stealthy ones) and anti-radiation

Keywords： low altitude     air defense radar     anti-stealth     anti-cruise missile     anti-antiradiation missile    

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Title Author Date Type Operation

Liver-directed treatment is associated with improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results from a retrospective multicenter trial

Journal Article

Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Journal Article

Design, synthesis and HIV-RT inhibitory activity of novel thiazolidin-4-one derivatives

Hua CHEN, Zaihong GUO, Qingmei YIN, Xiaoxu DUAN, Yunjing GU, Xiaoliu LI

Journal Article

Antibacterial and anti-flaming PA6 composite with metathetically prepared nano AgCl@BaSO

Wei Zhang, Boren Xu, Caihong Gong, Chunwang Yi, Shen Zhang

Journal Article

QUANTITATIVE STUDY ON ANTI-PEST ACTIVITY OF NATURAL PRODUCTS BASED ON VISUALIZATION FRAMEWORK OF KNOWLEDGE

Journal Article

Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD

Journal Article

A modular cable-driven humanoid arm with anti-parallelogram mechanisms and Bowden cables

Journal Article

Anti-biofouling strategies for implantable biosensors of continuous glucose monitoring systems

Journal Article

Lignin-derived dual-function red light carbon dots for hypochlorite detection and anti-counterfeiting

Journal Article

Modulatory effect on dyslipidemia and anti-atherosclerotic function of in newly diagnosed type 2 diabetes

SUN Mingxiao, WANG Yao, CHI Jiamin

Journal Article

Preparation of reverse osmosis membrane with high permselectivity and anti-biofouling properties for

Journal Article

Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)

Journal Article

Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion

Liyuan Chen, Qifeng Dang, Chengsheng Liu, Jun Chen, Lei Song, Xiguang Chen

Journal Article

Mobile CRISPR-Cas9 based anti-phage system in E. coli

Journal Article

Impact of Recent Regional Wars on Requirements of Ground based Air Defense Radars

Peng Jiating

Journal Article